Spring CLA sadrži visoku koncentraciju konjugirane linolne kiseline (CLA), esencijalne masne kiseline koju danas uglavnom slabo unosimo u sklopu naše prehrane. CLA je veoma važna za metabolizam masnih stanica jer djeluje na smanjenje njihovog nastanka te potiče njihovo sagorijevanje u mišićnim stanicama. Istraživanja su pokazala kako CLA ima i snažno antioksidativno djelovanje, smanjuje pojavu alergija te pridonosi zdravlju krvožilnog sustava te boljoj funkciji imuniteta.

SASTOJCI U PREPORUČENOJ DNEVNOJ DOZI (4 KAPSULE):

Konjugirana linolna kiselina (CLA): 2400 mg

Ekstrakt sjemenki lana: 60 mg

Krom: 52,8 µg (132% RDA)

• Conjugated Linoleic Acid Is Synthesized Endogenously in Lactating Dairy Cows by Delta-9-Desaturase
• Schiavon S, et al Effect of high or low protein ration combined or not with rumen protected conjugated linoleic acid (CLA) on meat CLA content and quality traits of double-muscled Piemontese bulls . Meat Sci. (2011)
• Santercole V, et al Total lipids of Sarda sheep meat that include the fatty acid and alkenyl composition and the CLA and trans-18:1 isomers . Lipids. (2007)
• Bölükbaşi SC Effect of dietary conjugated linoleic acid (CLA) on broiler performance, serum lipoprotein content, muscle fatty acid composition and meat quality during refrigerated storage . Br Poult Sci. (2006)
• McCrorie TA, et al Human health effects of conjugated linoleic acid from milk and supplements . Nutr Res Rev. (2011)
• Ip C, Scimeca JA, Thompson HJ Conjugated linoleic acid. A powerful anticarcinogen from animal fat sources . Cancer. (1994)
• Lee Y Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA . Nutr Res Pract. (2008)
• Analysis of conjugated linoleic acid isomers and content in french cheeses
• Lin H, et al Survey of the conjugated linoleic acid contents of dairy products . J Dairy Sci. (1995)
• Risérus U, et al Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome . Diabetes Care. (2002)
• Risérus U, et al Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men . Am J Clin Nutr. (2004)
• Goedecke JH, et al Conjugated linoleic acid isomers, t10c12 and c9t11, are differentially incorporated into adipose tissue and skeletal muscle in humans . Lipids. (2009)
• DeClercq V, Taylor CG, Zahradka P Isomer-specific effects of conjugated linoleic acid on blood pressure, adipocyte size and function . Br J Nutr. (2012)
• DeClercq V, Zahradka P, Taylor CG Dietary t10,c12-CLA but not c9,t11 CLA reduces adipocyte size in the absence of changes in the adipose renin-angiotensin system in fa/fa Zucker rats . Lipids. (2010)
• Rahman M, et al Conjugated linoleic acid (CLA) prevents age-associated skeletal muscle loss . Biochem Biophys Res Commun. (2009)
• Cheng WL, et al Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathway . J Agric Food Chem. (2004)
• Noone EJ, et al The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects . Br J Nutr. (2002)
• Brown JM, et al Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines . J Biol Chem. (2004)
• Brown JM, et al Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes . J Lipid Res. (2003)
• Papaetis GS, Orphanidou D, Panagiotou TN Thiazolidinediones and type 2 diabetes: from cellular targets to cardiovascular benefit . Curr Drug Targets. (2011)
• Eyjolfson V, Spriet LL, Dyck DJ Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans . Med Sci Sports Exerc. (2004)
• Moloney F, et al Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus . Am J Clin Nutr. (2004)
• Watras AC, et al The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain . Int J Obes (Lond). (2007)
• Syvertsen C, et al The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese . Int J Obes (Lond). (2007)
• Pariza MW, Park Y, Cook ME The biologically active isomers of conjugated linoleic acid . Prog Lipid Res. (2001)
• Tsuboyama-Kasaoka N, et al Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice . Diabetes. (2000)
• Evans M, et al Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes . J Nutr. (2002)
• Park Y, et al Effect of conjugated linoleic acid on body composition in mice . Lipids. (1997)
• Navarro V, et al The body fat-lowering effect of conjugated linoleic acid: a comparison between animal and human studies . J Physiol Biochem. (2006)
• Kamphuis MM, et al The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects . Int J Obes Relat Metab Disord. (2003)
• Conjugated Linoleic Acid Reduces Body Fat Mass in Overweight and Obese Humans
• Thom E, Wadstein J, Gudmundsen O Conjugated linoleic acid reduces body fat in healthy exercising humans . J Int Med Res. (2001)
• Metabolic effects of conjugated linoleic acid in humans: the Swedish experience
• Gaullier JM, et al Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans . Am J Clin Nutr. (2004)
• Blankson H, et al Conjugated linoleic acid reduces body fat mass in overweight and obese humans . J Nutr. (2000)
• Conjugated linoleic acid and oxidative stress
• Antioxidant effects of conjugated linoleic acid isomers in isolated human low-density lipoproteins
• Turpeinen AM, et al Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy . Br J Nutr. (2008)
• Whigham LD, et al Safety profile of conjugated linoleic acid in a 12-month trial in obese humans . Food Chem Toxicol. (2004)